Potential waveform innovation in 6G and, in particular, the dimension of Integrated Sensing and Communications (ISAC) have been perceived to be blocked by the signal processing capabilities of today’s receiver architectures. Setting the stage by introducing Zak-OTFS and how data-derived sensing functions to enable ISAC functionality in both terrestrial and NTN scenarios. Introducing the development by Virginia Tech researchers of an innovative Neural Receiver that can process sophisticated waveforms, without advanced training followed by detailing a demonstration Zak-OTFS implementation with ISAC capabilities based on the Neural Receiver and an NVIDIA Jetson(TM) hardware platform that will be used for in-depth ISAC R&D activities.