Communication standards such as 5G (Cellular), CDMA (Cellular), 802.11ax (wifi/BT), 802.16 (Wide area networks), Docsis 3.x (Cable), DVB-T2 and ATSC 3, incorporate complex multitone signals such as high order QAM (512,1024) and OFDM to efficiently transmit information. Even today’s satellite communication systems have gone from QPSK signals to relatively complex 8PSK and its variants. These complex signals are not very tolerant to nonlinear distortion that occurs in high power amplifiers which are part of transmit chain. To minimize distortion, and optimize efficiency, amplifiers must be operated close to boundary between linear and non-linear regions. To identify an appropriate operating point, amplifier gain compression must be tested and characterized using real world signals. Reviewing traditional gain compression measurement methods and discusses an alternative method of gain compression measurement with CCDF curves using real world like signals.